Human; Mouse; Rat; Dog; Monkey, Min 2 compounds
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Both IV and PO, 3 rats for each dosing route8-10 timepoints over 24 hoursIV 2mg/kg PO 5mg/kg
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Min 5 compounds, Five major CYP isoform (3A4,1A2,2C19,2D6,2C9), IC50 of inhibition
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