FITC标记的环指蛋白125抗体
产品名称： FITC标记的环指蛋白125抗体
英文名称： Anti-RNF125/FITC
产品编号： HZ-9250R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RNF125/FITC Conjugated antibody
FITC标记的环指蛋白125抗体
| 产品编号 | bs-9250R-FITC |
| 英文名称 | Anti-RNF125/FITC |
| 中文名称 | FITC标记的环指蛋白125抗体 |
| 别 名 | T cell RING activation protein 1; E3 ubiquitin protein ligase RNF125; Ring finger protein 125; RNF 125; T cell ring protein identified in activation screen; TRAC 1; TRAC1; RN125_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRAC1/RNF125 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. TRAC-1 (T-cell RING activation protein 1), also known as RNF125 (ring finger protein 125) or E3 ubiquitin-protein ligase RNF125, is a 232 amino acid novel E3 ubiquitin ligase that functions as a positive regulator in the T-cell receptor signaling pathway. Expressed predominantly in lymphoid tissues such as spleen, thymus and bone marrow, TRAC-1 has been found to inhibit pathogen-induced cytokine production and down-regulates HIV replication. Function: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Tissue Specificity: Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 54941 Human Entrez Gene: 67664 Mouse Entrez Gene: 361296 Rat Omim: 610432 Human SwissProt: Q96EQ8 Human SwissProt: Q9D9R0 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
环型锌指基序存在于许多病毒和真核蛋白质中，并且由能够结合两个锌原子的保守的富含半胱氨酸的结构域构成。含有保守结构域的蛋白质一般参与蛋白质降解的泛素化途径。Trac-1（T细胞环激活蛋白1），也称为RNF125（环指蛋白125）或E3泛素蛋白连接酶RNF125，是一种232氨基酸新颖的E3泛素连接酶，在T细胞受体信号通路中起着正调节作用。主要表达在淋巴组织如脾脏、胸腺和骨髓中，已发现Trac-1抑制病原体诱导的细胞因子产生并下调HIV复制。