INHBB Pre-design Chimera RNAi
产品名称： INHBB Pre-design Chimera RNAi
英文名称： INHBB Pre-design Chimera RNAi
产品编号： H00003625-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens inhibin, beta B (activin AB beta polypeptide) (INHBB), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_002193
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 3625
- Gene Name:
- INHBB
- Gene Alias:
- MGC157939
- Gene Description:
- inhibin, beta B
- Omim ID:
- 147390
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq
- Other Designations:
- Inhibin, beta-2,activin AB beta polypeptide,inhibin beta B subunit
- Interactome
- Related Disease
- Breast Neoplasms
- Cleft Lip
- Cleft Palate
- Disease Models, Animal
- Genetic Predisposition to Disease
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Glandular and Epithelial
- Obesity
- Ovarian cancer
- Ovarian Failure, Premature
- Ovarian Neoplasms
- Polycystic Ovary Syndrome
- Prostate cancer
- Prostatic Neoplasms
- Puberty, Delayed
- Puberty, Precocious
- Testicular Neoplasms
- Thrombophilia
- Tobacco Use Disorder