FITC标记的蛋白BOC抗体
产品名称： FITC标记的蛋白BOC抗体
英文名称： Anti-Protein BOC/FITC
产品编号： HZ-12322R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Protein BOC/FITC Conjugated antibody
FITC标记的蛋白BOC抗体
| 英文名称 | Anti-Protein BOC/FITC |
| 中文名称 | FITC标记的蛋白BOC抗体 |
| 别 名 | Boc homolog (mouse); Brother of CDO; Protein BOC; brother of CDO precursor; Protein BOC; BOC_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 神经生物学 干细胞 细胞表面分子 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Zebrafish, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 121kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Protein BOC |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: BOC is a receptor-like, single pass membrane protein belonging to the cell surface molecule subfamily of the Immunoglobulin/fibronectin type-III repeat family within the immunoglobulin superfamily. It contains three fibronectin type-III domains and four Immunoglobulin-like C2-type domains in its extracellular region. The intracellular region of BOC is not required for proper function. BOC localizes to the cell membrane and is ubiquitously expressed with highest expression levels in skeletal muscle and small intestine. Its mRNA expression is down-regulated by Ras. BOC is involved in accelerating myoblast differentiation and is dependent on CDO for its activity. BOC and CDO are co-expressed in muscle precursors and are components of a receptor complex that mediates cell-cell interactions important in myogenesis. Overexpression of BOC results in enhanced differentiation of myoblast cells. In addition, BOC is a target and signaling component of the Shh pathway. Function: Brother of CDO (BOC) interacts with Hedgehog (Hh) via a specific FNIII domain and belongs to the Ihog (interference hedgehog) family of proteins. Zebrafish BOC is expressed predominantly in the developing neural plate and later in the neural tube and developing brain. Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation. Subcellular Location: Cell membrane; Single pass type I membrane protein. Note: Enriched at sites of cell-cell contact. Tissue Specificity: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa. Post-translational modifications: N-glycosylated. Similarity: Contains 3 fibronectin type-III domains. Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 512018 Cow Entrez Gene: 487979 Dog Entrez Gene: 100712740 Guinea pig Entrez Gene: 100071428 Horse Entrez Gene: 91653 Human Entrez Gene: 117606 Mouse Entrez Gene: 100626085 Pig Entrez Gene: 100347510 Rabbit Entrez Gene: 360715 Rat Entrez Gene: 334628 Zebrafish Omim: 608708 Human SwissProt: Q9BWV1 Human SwissProt: Q6AZB0 Mouse Unigene: 591318 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
BOC是属于免疫球蛋白超家族中免疫球蛋白/纤维连接蛋白III型重复家族的细胞表面分子亚家族的受体样单程膜蛋白。它包含三个纤连蛋白III型结构域和四个免疫球蛋白样C2型域在其胞外区。Boc的细胞内区域不需要适当的功能。BOC定位于细胞膜，在骨骼肌和小肠中普遍表达，表达水平最高。RAS下调其mRNA表达。BOC参与加速成肌细胞分化，并依赖于CDO对其活性的影响。BOC和CDO在肌肉前体共同表达，并且是介导细胞与细胞间相互作用的受体复合物的组成部分，细胞与细胞间相互作用在肌肉发生中很重要。BOC的过度表达导致成肌细胞的分化增强。此外，BOC是Shh信号通路的靶和信号成分。